Zinc Deficiency is Associated with Elevation of High Sensitive C-reactive Protein in Hemodialysis Patients

Zinc Hemodialysis High sensitive C-reactive protein Background: Numerous studies claim that the oxidative stress is elevated in hemodialysis patients. The aim of this study is to investigate the serum level of zinc in hemodialysis patient in Isfahan, Iran. Method: In this study 100 hemodialysis patients from hemodialysis section of Alzahra hospital and Isfahan Noor hospital among 20132014 years were recruited. Serum level of zinc, albumin and high sensitive C-reactive protein (hs-CRP) was measured by atomic absorption, colorimetric and agglutination method, respectively. Result: patients serum zinc level was 96.7± 20μg/dl and 12% of hemodialysis patients showed a zinc deficiency. Serum Albumin was significantly lower than normal (3.73± 0.51) and hs-CRP was significantly higher (16.78± 9.71). Statistical analysis showed a significant relation between serum zinc and hs-CRP. Conclusion: this study demonstrates there is an inverse relation between serum level of zinc and hs-CRP. This relation was statistically significant. This study insists on the importance of nutritional supplementation of zinc in hemodialysis patients.